Is the mattress protector hypoallergenic? April 20, 2022 13:43 Updated Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Is the mattress protector a full encasement? Do you use any chemical fire retardants (FR) in your mattresses? Will the mattress protector reduce breathability of the mattress? How high are your foundations? How much storage is under the foundation? Do your sheets work on a mattress over 11" thick?