Is the mattress protector hypoallergenic? April 20, 2022 13:43 Updated Yes, the mattress protector is made of cotton terry, which is designed to be both easy care and hypo-allergenic. Related articles Will the mattress protector reduce breathability of the mattress? Is the mattress protector a full encasement? Do your sheets work on a mattress over 11" thick? Can I adjust the firmness of the premium shredded foam pillow? Will your mattresses develop body impressions?